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The role of glutathione in carboplatin ototoxicity in the chinchilla
D Henderson, BH Hu, SL McFadden, XY Zheng, D Ding
Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, USA
Correspondence Address:
D Henderson
Center for Hearing and Deafness, State University of New York at Buffalo, 3435 Main Street, 215 Parker Hall, Buffalo, New York 14214
USA
The role of glutathione in carboplatin ototoxicity was investigated in the chinchilla. Chinchillas hearing was tested with both distortion product otoacoustic emissions (DPOAE) and evoked potentials recorded from a chronic electrode in the inferior colliculus (IC). All subjects had an osmotic pump fitted to their right ear and it received buthionine sulfoximine (BSO) at a dose of 15 mM delivered at 5 ml per hour for 14 days. A group (N=4) was given a double dose of carboplatin (25 mg/kg i.p. for 2 days). The pump was implanted three days before the carboplatin dose. The BSO treated ears showed a greater loss in both evoked potential and DPOAE measures, as well as substantially fewer missing hair cells. The results implicate reactive oxygen species (ROS) as a common factor in ototoxic reactions because suppression of glutathione antioxidant leads to greater ototoxic reactions.
How to cite this article:
Henderson D, Hu B H, McFadden S L, Zheng X Y, Ding D. The role of glutathione in carboplatin ototoxicity in the chinchilla.Noise Health 2000;3:1-10
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How to cite this URL:
Henderson D, Hu B H, McFadden S L, Zheng X Y, Ding D. The role of glutathione in carboplatin ototoxicity in the chinchilla. Noise Health [serial online] 2000 [cited 2023 May 31 ];3:1-10
Available from: https://www.noiseandhealth.org/article.asp?issn=1463-1741;year=2000;volume=3;issue=9;spage=1;epage=10;aulast=Henderson;type=0 |
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