Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
Noise & Health  
 Next article
 Previous article
Table of Contents

Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Citation Manager
Access Statistics
Reader Comments
Email Alert *
Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded25    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


Year : 2020  |  Volume : 22  |  Issue : 106  |  Page : 70--76

The effects of hyperinsulinemia on cochlear functions

1 Department of Internal Medicine, Başkent University Ankara Hospital, Ankara, Turkey
2 Department of Otorhinolaryngology, Başkent University Ankara Hospital, Ankara, Turkey
3 Department of Endocrinology and Metabolism, Başkent University Ankara Hospital, Ankara, Turkey

Correspondence Address:
Arzu Or Koca
Keçiören Health Administration and Research Center, Department of Endocrinology and Metabolism, Kuşcağız, 06010, Keçiören, Ankara
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/nah.NAH_41_20

Rights and Permissions

Context: Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases. Aim: We aimed to investigate the auditory functions in hyperinsulinemic individuals. Settings and Design: A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of ≥2.5) constituted the case group, 88 patients with HOMA-IR values of <2.5 constituted the control group of the study. Material and Methods: The 75 g oral glucose tolerance test, blood biochemistry tests, hormonal analysis, audiological assessment, electrocochleography (EcochG), and transient evoked otoacoustic emissions (TEOAE) testing were performed. Statistical Analysis: One-way analysis of variance and Kruskal–Wallis analysis of variance were used for the comparison of the metabolic and ear parameters in the normal glucose tolerance (NGT), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) groups. The chi-square test was used to compare nominal variables. Spearman and Pearson correlation coefficients were used for the correlation analyses of continuous variables. Results: The pure tone audiometry at 0.5, 1, 2, and 4 kHz was better in the case group than in the control group. A positive correlation was found between HbA1c and right ear 0.5, 1, 4, and 8 kHz threshold values and left ear 2, 4, 6, and 8 kHz threshold values. A negative correlation was found between HbA1c and speech discrimination scores. The right ear 1.00 and 2.83 kHz TEOAE measurements in the individuals with NGT were found higher than those in patients with IGT, and the 1.42 kHz TEOAE measurements and reproducibility were found higher than those in patients with IFG. The left ear 1.00 and 1.42 kHz TEOAE measurements of the IGT patients were found lower than those of IFG and NGT patients. Conclusion: We showed that hearing was worsening in hyperinsulinemic patients and prediabetic conditions were related to hearing function impairment.


Print this article     Email this article