| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 20
| Issue : 97 | Page : 232--239 |
Evaluation of Effect of Garlic Aged Extracts and Vitamin B12 on Noise-Induced Hearing Loss
Muammer M Sahin1, Mehmet B Uğur2, Recep Karamert2, Sinem Aytekin3, Burak Kabiş4, Mehmet Düzlü2, Cemile Seymen5, Çiğdem Elmas5, Çağıl Gökdoğan4, Serkan Ünlü6
1 Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Numune Hospital, Ankara, Turkey
2 Department of Otorhinolaryngology, Head and Neck Surgery, Ankara Gazi University Hospital, Ankara, Turkey
3 Department of Pathology, Ankara Gazi University Hospital, Ankara, Turkey
4 Department of Audiology, Ankara Gazi University Hospital, Ankara, Turkey
5 Department of Histology and Embryology, Ankara Gazi University Hospital, Ankara, Turkey
6 Pharmacology Department, Ankara Gazi University Institute of Health Sciences, Ankara, Turkey
Correspondence Address:
Muammer M Sahin
Ankara Numune Hastanesi, Kulak Burun Boğaz Kliniği, Hacettepe, Talatpasa Bulvarı No. 44, 06230 Altındağ/Ankara
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/nah.NAH_33_18
Objective: This study investigated effects of S-allylmercaptocysteine (SAMC), diallyl disulfide (DADS), and vitamin B12 on inner ear functions and morphology after long-period high-level broadband noise exposure. Materials and Methods: Twenty-four healthy rats were randomly divided into four groups. First group was chosen as the control group. Vitamin B12, SAMC, and DADS were applied to other groups for 4 weeks. On the 14th day, each group was exposed to broadband noise. Auditory brainstem response test was performed before and immediately after noise exposure and repeated on the 2nd and 14th day. Results: Permanent threshold shifts were significantly lower in groups treated with vitamin B12, SAMC, and DADS. Histologically, cochleae of SAMC and DADS groups were found to be better preserved than the cochleae of vitamin B12 and control groups. Conclusion: Physiologically and histologically, SAMC and DADS reduced the long-term effects of noise. However, physiological recovery was not consistent with the morphological findings in vitamin B12 group.
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