Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
Noise & Health  
 Next article
 Previous article
Table of Contents

Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Citation Manager
Access Statistics
Reader Comments
Email Alert *
Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded35    
    Comments [Add]    
    Cited by others 5    

Recommend this journal


Year : 2014  |  Volume : 16  |  Issue : 68  |  Page : 18--25

Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

1 Department of Neurology, Mengücek Gazi Training and Research Hospital, Erzincan, Turkey
2 Department of Neurology, Faculty of Medicine, Balıkesir University, Balıkesir, Turkey
3 Department of Biochemistry, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
4 Department of Neurology, Faculty of Medicine, Turgut Özal University, Ankara, Turkey
5 Department of Neurology, Faculty of Medicine, Gazi University, Ankara, Turkey

Correspondence Address:
Emine Rabia Koc
Department of Neurology, Balıkesir Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Çağış Yerleşkesi, 10145 Balıkesir
Login to access the Email id

Source of Support: This work supported by Scientific Research Fund of Fatih University,, Conflict of Interest: None

DOI: 10.4103/1463-1741.127849

Rights and Permissions

The problem of noise has recently gained more attention as it has become an integral part of our daily lives. However, its influence has yet to be fully elucidated. Other than being an unpleasant stimulus, noise may cause health disorders through annoyance and stress, including oxidative stress. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, may possess antioxidant properties. Based on rat models, our project investigates the effect of rosuvastatin on noise-induced oxidative stress in the brain tissue. Thirty-two male Wistar albino rats were used. The rats were divided into four groups: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage, and control. After the data had been collected, oxidant and antioxidant parameters were analyzed in the cerebral cortex, brain stem, and cerebellum. Results indicated that superoxide dismutase values were significantly decreased in the cerebral cortex, while malondialdehyde values in the brainstem and cerebellum were significantly increased in the group with only noise exposure. Superoxide dismutase values in the brainstem were significantly increased, but nitric oxide values in the cerebellum and brainstem and malondialdehyde values in the cerebellum and cerebral cortex were significantly decreased in the group where only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased superoxide dismutase values in the cerebral cortex and brainstem, but significantly reduced malondialdehyde values in the brain stem. Consequently, our data show that brain tissue was affected by oxidative stress due to continued exposure to noise. This noise-induced stress decreases with rosuvastatin therapy.


Print this article     Email this article