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Year : 2013  |  Volume : 15  |  Issue : 65  |  Page : 231--236

Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population


1 Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China
2 Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center; Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China
3 Center of Prevention and Health, Yizheng Hospital, Drum Tower Hospital Group of Nanjing, Yizheng, China
4 Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, Nanjing, China

Correspondence Address:
Zhengdong Zhang
Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, 818 East Tianyuan Road, Nanjing 211166
China
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Source of Support: This study was mainly supported by Projects of Jiangsu Society Development (BS2005661), Jiangsu Province’s Outstanding Medical Academic Leader program, the National Natural Science Foundation of China (81230068, and 30972444), the Key Program of Natural Science Foundation of Jiangsu Province (BK2010080, and BK2010575), the Qing Lan Project of Jiangsu Provincial Department of Education, and the Priority Academic Program development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine), Conflict of Interest: None


DOI: 10.4103/1463-1741.113517

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DNA methyltransferase 1 (DNMT1) plays a crucial role in maintaining of methylation and chromatin stability. And mutations in DNMT1 can induce one form of neurodegenerative diseases with dementia and sensorineural hearing loss. To assess whether single nucleotide polymorphisms (SNPs) or haplotypes of DNMT1 are related to noise-induced hearing loss (NIHL) in a Chinese population, we genotyped three functional polymorphisms (rs12984523, rs16999593, and rs2228612) in a case-control study involving 615 NIHL cases and 644 controls. However, no significant association was detected between these three SNPs and NIHL susceptibility in the Chinese population. Our data suggested that the DNMT1 polymorphisms may not contribute to risk of NIHL in the Chinese population.






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