Home Email this page Print this page Bookmark this page Decrease font size Default font size Increase font size
Noise & Health  
 CURRENT ISSUE    PAST ISSUES    AHEAD OF PRINT    SEARCH   GET E-ALERTS    
 
 Next article
 Previous article
Table of Contents

Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Citation Manager
Access Statistics
Reader Comments
Email Alert *
Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7984    
    Printed132    
    Emailed2    
    PDF Downloaded30    
    Comments [Add]    
    Cited by others 4    

Recommend this journal

 

 ARTICLE
Year : 2013  |  Volume : 15  |  Issue : 65  |  Page : 217--223

Behavioral and plasma monoamine responses to high-speed railway noise stress in mice


Department of Environmental Science and Institute of Environmental Pollution and Control Technology, Zhejiang University, Hangzhou, China

Correspondence Address:
Guoqing Di
Nongshenghuan Building B388, Zijingang Campus, Zhejiang University, Yuhangtang Road 866, Hangzhou, Zhejiang Province 310058
China
Login to access the Email id

Source of Support: The National Nature Science Foundation of China (Grant No. 11174251) and in part by the National Public Benefit Research Foundation (Grant No. 200809142),, Conflict of Interest: None


DOI: 10.4103/1463-1741.113506

Rights and Permissions

Studies have reported that railway noise causes stress responses. To evaluate the effects of high-speed railway (HSR) noise on behaviors and plasma monoamines. Institute of cancer research mice were exposed to previously recorded HSR noise for 53 days. The noise was arranged according to the HSR's 24-h traffic number and adjusted to a day-night equivalent continuous A-weighted sound pressure level (Ldn ) of 70 dB (A). The open field test (OFT) and the light/dark box test were applied to observe mice behaviors. High performance liquid chromatography-fluorimetric detection was performed to determine the concentrations of plasma norepinephrine (NE), dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT). Data were analyzed by two-way analysis of variance using SPSS 16.0. After 53 days of noise exposure, center time and the frequency of line crossing of the exposed mice decreased significantly in the OFT compared with the control group. Meanwhile, transitions and the time spent in the lit compartment of the exposed group decreased significantly in the light/dark box test. After 40 days of HSR noise exposure, the concentrations of plasma DA of the exposed group were significantly higher than those of the control group, while the plasma NE and 5-HT concentrations showed no significant difference between the two groups. The behavioral tests indicate that 70 dB (A) HSR noise can result in anxiety-like behaviors in mice. The physiological results show that plasma DA is more sensitive to HSR noise compared with NE and 5-HT.






[FULL TEXT] [PDF]*


        
Print this article     Email this article