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Year : 2006  |  Volume : 8  |  Issue : 32  |  Page : 108--113

Salivary chromogranin A as a measure of stress response to noise

1 Department of Environmental Risk Management, Kibi International University, Japan
2 Department of Urban and Environmental Engineering, Kyoto University, Japan
3 Department of Health Science, Asahikawa Medical College, Japan

Correspondence Address:
Masamitsu Miyakawa
Department of Environmental Risk Management, Kibi International University
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1463-1741.33951

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Effects of noise on the secretion of salivary chromogranin A (CgA), which is considered to be a substitute measure of catecholamines, were investigated in a laboratory experiment. This study included 20 male subjects with normal hearing; their ages ranged from 21 to 24 years. Prior to the experiment, the subjects were asked to answer a questionnaire containing the 28-item General Health Questionnaire (GHQ-28) and Weinstein's noise sensitivity scale. White noise at 90 dB was presented to the subjects for 15 min with 15-minute-rest periods before and after noise exposure. It was shown that salivary CgA levels increased significantly during noise exposure and decreased immediately after it (Friedman's test, p = 0.001, two tailed). This result suggests that salivary CgA can be used to measure the stress response to noise. Furthermore, individual differences in the change in salivary CgA levels were discussed in relation to the subjective responses of the participants to the questionnaire. Some subjects showed prolonged elevation in the salivary CgA levels and the others showed immediate recovery or no effects. These individual differences correlated with the score on the somatic symptoms in GHQ-28; this implies that the score on the somatic symptoms in GHQ-28 could be a measure of physiological sensitivity to noise.


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